Protein Released from Fat After Exercise Improves Glucose
The researchers found that exercise training causes dramatic changes to fat. Additionally, they discovered that this “trained” fat releases factors into the bloodstream that can have positive effects on health.
It’s known that fat cells secrete proteins called adipokines, and that many adipokines increase with obesity. In contrast to the negative effects of many adipokines, the study identified transforming growth factor beta 2 (TGF-beta 2) as an adipokine released from adipose tissue (fat) in response to exercise that actually improves glucose tolerance.
Analysis identified TGF beta 2 as one of the proteins upregulated in exercise. Additional investigation confirmed that levels of this one adipokine actually increased in the fat tissue as well as in the bloodstream with exercise.
These findings suggest that TGF beta 2 may be a potential therapy for treatment of high blood sugar, and eventually a potential therapy for type 2 diabetes.