Risk of Diabetes Is Noticeably Reduced After Weight Loss
A large real-world study in half a million adults showed that intentional loss of around 13% of body weight reduces the relative risk of developing type 2 diabetes by around 40% in obese people. The results of the huge study managed by Novo Nordisk were presented during the virtual European and International Congress on Obesity (ECOICO 2020). This was not the only astonishing result but also reductions in the risk of sleep apnea by 22%-27%, hypertension by 18%-25%, and dyslipidemia by 20%-22% were found. Anonymized data from over half a million patients documented in the Clinical Practice Research Datalink (CPRD) database, which holds information from 674 general practices in the UK were used in the study. All participants had a body mass index of 25.0–50.0 kg/m2 at the beginning of the follow-up, between January 2001 and December 2010. Patients have been advised to lose weight by taking more exercise, or have been referred to a dietician. While some had been prescribed anti-obesity medications available between 2001-2010 and Less than 1% had been referred for bariatric surgery. Participants were then split into two categories based on their weight pattern during the 4-year period: one whose weight remained stable (492,380 individuals with BMI change within –5% to +5%) and one who lost weight (60,573 with BMI change –10% to –25%). The median change in BMI in the second group was – 13%. The benefits of losing 13% of body weight were then determined for three risk profiles: BMI reduction from 34.5 to 30 kg/m² (obesity class I level); 40.3 to 35 kg/m² (obesity class II level), and 46 to 40 kg/m² (obesity class III level). Study authors mentioned that study strengths included the large number of participants and the relatively long follow-up period. While the observational nature of the study limited the ability to know the ways in which the participants who lost weight may have differed from those who maintained or gained weight.
Source: Medscape. “Small Weight Loss Produces Impressive Drop In Type 2 Diabetes Risk”. https://www.medscape.com/viewarticle/937162. Accessed 13 Sept 2020.