Intravenous Administration of Tuberculosis Vaccine Boosts Efficacy
A recent study published in Nature and performed by scientists from the University of Pittsburgh’s Center for Vaccine Research in Pennsylvania showed that intravenous bacillus Calmette–Guérin (BCG) prevents or significantly limits Mycobacterium tuberculosis infection in highly susceptible rhesus non-human primates (Macaca mulatta). This finding has implications for vaccine delivery and clinical development. Immune correlates and mechanisms of vaccine-elicited protection against tuberculosis can also be defined based on the study’s results.
Source: Darrah PA, Zeppa JJ, Maiello P, et al. Prevention of tuberculosis in macaques after intravenous BCG immunization. Nature 2020 ;577:95–102. DOI : 10.1038/s41586-019-1817-8